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Quinone reductase: Difference between revisions

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__TOC__
__TOC__
==Function==
==Function==
'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone. '''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome.    The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria. '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone.  See [[Electron Transport & Oxidative Phosphorylation]].
*'''Quinone reductase type 1 (QR1)''' reduces quinines to the non-toxic hydroquinone.  
*'''Quinone reductase type 2 (QR2)''' or '''ribosyldihydronicotinamide dehydrogenase [quinone]''' catalyzes the reduction of adrenochrome.     
* '''Sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria.  
* '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone.
*'''Na(+)-translocating NADH-quinone reductase''' is the Na(+) pumping respiratory complex found in prokaryotes<ref>PMID:25052842</ref>.   
See [[Electron Transport & Oxidative Phosphorylation]].


== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==
== NADH Quinone oxidoreductase type 1 (NQO1) in complex with its potent inhibitor dicoumarol ==
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{{Clear}}
{{Clear}}
The quinone ES936 causes irreversible inhibition of the NQO1. <scene name='2f1o/Align2/5'>Alignment</scene> of the hNQO1 dimer in complex with <font color='red'><b>ES936 (red)</b></font> ([[1kbq]]) with the hNQO1−dicoumarol complex ([[2f1o]]) yields 0.45Å RMSD for the 546 Cα atoms. The ES936 causes structural change only in the position of Phe 232. The movement of this residue is smaller than that caused by dicoumarol. The <scene name='2f1o/Align2/6'>distance</scene> between Tyr 128 and Phe 232 in the hNQO1−ES936 complex is only ~7 Å, while in the hNQO1−dicoumarol complex it is ~12 Å.
The quinone ES936 causes irreversible inhibition of the NQO1. <scene name='2f1o/Align2/5'>Alignment</scene> of the hNQO1 dimer in complex with <font color='red'><b>ES936 (red)</b></font> ([[1kbq]]) with the hNQO1−dicoumarol complex ([[2f1o]]) yields 0.45Å RMSD for the 546 Cα atoms. The ES936 causes structural change only in the position of Phe 232. The movement of this residue is smaller than that caused by dicoumarol. The <scene name='2f1o/Align2/6'>distance</scene> between Tyr 128 and Phe 232 in the hNQO1−ES936 complex is only ~7 Å, while in the hNQO1−dicoumarol complex it is ~12 Å.
</StructureSection>


== 3D Structures of Quinone reductase ==
== 3D Structures of Quinone reductase ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Quinone reductase 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Quinone reductase type 1
 
**[[3jsx]] – hQR1 + coumarine derivative<br />
**[[2f1o]] – hQR1 + dicoumarol<br />
**[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />
 
*Quinone reductase type 2 or ribosyldihydronicotinamide dehydrogenase [quinone]
 
**[[4qod]] – hNQO2 - human<br />
**[[4qof]] – hNQO2 + FMN<br />
**[[1qr2]], [[3fw1]], [[4qoe]] – hNQO2 + FAD<br />
**[[3o2n]], [[3g5m]], [[3gam]] – hNQO2 + FAD + PET agent<br />
**[[3ovm]], [[3owh]], [[3owx]] – hNQO2 + FAD + carbamate derivative<br />
**[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hNQO2 + FAD + acetamide derivative<br />
**[[3ox2]], [[4xdh]], [[4xdg]] - hNQO2 + FAD + indole derivative<br />
**[[3ox3]] - hNQO2 + FAD + carboxamide derivative<br />
**[[4u7f]], [[4u7g]], [[4u7h]] - hNQO2 + FAD + imidazole derivative<br />
**[[4zvk]], [[5buc]] - hNQO2 + FAD + ethidium<br />
**[[4zvm]] - hNQO2 + FAD + doxorubicin<br />
**[[2qmy]] – hNQO2 + FAD + adrenochrome<br />
**[[2qr2]] – hNQO2 + FAD + menadione<br />
**[[2qmz]] – hNQO2 + FAD + dopamine<br />
**[[4qog]] – hNQO2 + FAD + melatonin<br />
**[[1sg0]], [[4qoh]] – hNQO2 + FAD + resveratol<br />
**[[4qoj]] – hNQO2 + FMN + resveratol<br />
**[[4qoi]] – hNQO2 + FMN + melatonin<br />
**[[3nhu]], [[3nhs]], [[3nhr]], [[3nhp]], [[3nhl]], [[3nhk]], [[3nhj]], [[3nhf]], [[3nfr]], [[3nhw]], [[3nhy]], [[3uxe]], [[3uxh]] - hNQO2 + FAD + quinoline derivative<br />
**[[3te7]], [[3tem]], [[4zvl]], [[4zvn]], [[3tzb]] – hNQO2 + FAD + acridine derivative<br />
**[[2bzs]], [[1xi2]], [[1zx1]], [[3o73]], [[5lbw]], [[5lbz]], [[5lby]] – hNQO2 + FAD + anti-cancer prodrug<br />
**[[4fgj]], [[4fgk]], [[4fgl]] – hNQO2 + FAD + anti-malaria drug<br />
**[[5lbt]], [[5lbu]] – hNQO2 + FAD + anti-wart drug<br />
**[[4gqi]], [[4gr9]] – hNQO2 + FAD + ligand<br />
 
*Sulfide-quinone reductase or Sulfide-quinone oxidoreductase
 
**[[6mo6]], [[6mp5]], [[6oi5]] – hSQR + FAD<br />
**[[6oic]], [[6oib]], [[6oi6]] – hSQR + FAD + CoQ<br />
**[[3hyv]] – AaSQR + FAD – ''Aquifex aeolicus''<br />
**[[3hyw]] – AaSQR + FAD + decylubiquinone<br />
**[[3hyx]] – AaSQR + FAD + Aurachin C<br />
**[[3h8l]], [[3h8i]] – AaSQR + FAD + trisulfane<br />
**[[3t0k]] – AfSQR + FAD + trisulfide + decylubiquinone - ''Acidithiobacillus ferrooxidabs''<br />
**[[3t14]] – AfSQR + FAD + disulfide<br />
**[[3t2y]] – AfSQR (mutant) + FAD + disulfide<br />
**[[3t2k]], [[3t2z]] – AfSQR + FAD + trisulfane<br />
**[[3t31]] – AfSQR + FAD + decylubiquinone<br />
 
*NADPH-quinone reductase or NADPH-quinone oxidoreductase or NADP dehydrogenase [quinone]
 
**[[1d4a]], [[5ea2]] - hNQO1 + FAD<br />
**[[5a4k]] - hNQO1 (mutant) + FAD<br />
**[[3jsx]] – hNQO1 + FAD + chromen derivative<br />
**[[6fy4]] – hNQO1 + FAD + pyrrolidine derivative<br />
**[[2f1O]], [[4cet]] – hNQO1 + FAD + dicoumarol<br />
**[[5fuq]] – hNQO1 (mutant) + FAD + dicoumarol<br />
**[[4cf6]] – hNQO1 (mutant) + FAD + cibacron<br />
**[[1yb5]] – hNQO1 + NADP<br />
**[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQRO1 + FAD + anti-cancer prodrug<br />
**[[1dxo]] - hNQO1 + FAD + quinone derivative<br />
**[[1kbo]], [[1kbq]] - hNQO1 + FAD + indole derivative<br />
**[[1dxq]] - mNQO1 + FAD - mouse<br />
**[[3ha2]] – NQO1 – ''Pediococcus pentosaceus''<br />
 
*Quinone reductase


**[[1qrd]] – QR + bicarbon blue + duroquinone - rat<br />
**[[4gi5]] – QR + FAD – ''Klebsiella pneumoniae''
}}
==References==
==References==
<ref group="xtra">PMID:10706635</ref> <ref group="xtra">PMID:16700548</ref> <references group="xtra"/>
<ref group="xtra">PMID:10706635</ref> <ref group="xtra">PMID:16700548</ref> <references group="xtra"/>
 
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
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