7k4e: Difference between revisions

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-'''Unreleased structure'''
-The entry 7k4e is ON HOLD  until Paper Publication
+==Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30==
+<StructureSection load='7k4e' size='340' side='right'caption='[[7k4e]], [[Resolution|resolution]] 4.34&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7k4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4E FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.34&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VUJ:5-({4-[(1R,4S)-3-methyl[1,2,3,4-tetrahydro[1,1-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one'>VUJ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4e OCA], [https://pdbe.org/7k4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4e RCSB], [https://www.ebi.ac.uk/pdbsum/7k4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4e ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRPV6_HUMAN TRPV6_HUMAN] Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.[UniProtKB:Q91WD2]<ref>PMID:11097838</ref> <ref>PMID:11248124</ref> <ref>PMID:11278579</ref> <ref>PMID:15184369</ref> <ref>PMID:23612980</ref>
-Authors:
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Nadezhdin KD]]
+[[Category: Neuberger A]]
+[[Category: Singh AK]]
+[[Category: Sobolevsky AI]]