7d8b: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7d8b is ON HOLD
+==Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways==
+<StructureSection load='7d8b' size='340' side='right'caption='[[7d8b]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7d8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8B FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8b OCA], [https://pdbe.org/7d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8b RCSB], [https://www.ebi.ac.uk/pdbsum/7d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
-Authors: Frosi, Y., Lin, Y.C., Jiang, S., Brown, C.J.
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
-Description: Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Brown, C.J]]
+__TOC__
-[[Category: Frosi, Y]]
+</StructureSection>
-[[Category: Jiang, S]]
+[[Category: Homo sapiens]]
-[[Category: Lin, Y.C]]
+[[Category: Large Structures]]
+[[Category: Brown CJ]]
+[[Category: Frosi Y]]
+[[Category: Jiang S]]
+[[Category: Lin YC]]