Mevalonate kinase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2hfu' size='340' side='right' caption='Mevalonate kinase complex with mevalonate (PDB code [[2hfu]]).' scene='86/864102/Cv/1'>
-<StructureSection load='6mde' size='340' side='right' caption='Caption for this structure' scene=''>
 __TOC__
 == Function ==
-'''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>.  MK catalyzes the conversion of mevalonate to 5-phosphomevalonate.
+'''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>. MK catalyzes the conversion of mevalonate to 5-phosphomevalonate.
+See also [[Mevalonate pathway]]
 == Disease ==
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 == Structural highlights ==
+The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/7'>deep cleft</scene> between the 2 domains forming <scene name='86/864102/Cv/6'>H-bonds and hydrophobic interactions</scene><ref>PMID:17397541</ref>. Water molecules are shown as red spheres.
 ==3D structures of mevalonate kinase==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 [[2r3v]] - hMK - human<br />
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 == References ==
 <references/>
+[[Category:Topic Page]]