Phospholipase D: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
</StructureSection>
==3D structures of phospholipase D==
==3D structures of phospholipase D==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Phospholipase D 3D structures]]


[[6u8z]] – hPLD1 catalytic domain 330-500, 643-1074 – human<br />
</StructureSection>
[[6ohr]] – hPLD1 catalytic domain + inhibitor<br />
[[6ohm]], [[6oho]] – hPLD2 catalytic domain 294-933<br />
[[6ohq]], [[6ohs]], [[6ohp]] – hPLD2 catalytic domain + inhibitor<br />
[[4rw3]] – bsPLD – brown spider<br />
[[4rw5]] – bsPLD (mutant)<br />
[[3rlg]], [[3rlh]] – PLD (mutant) – ''Loxosceles intemedia''<br />
[[4q6x]] – PLD – cave spider<br />
[[2ze4]], [[1v0r]], [[1v0s]], [[1f0i]] – SaPLD – ''Streptomyces antibioticus''<br />
[[1v0v]], [[1v0w]] – SaPLD + phosphite<br />
[[1v0y]] – SaPLD + phosphatidylcholine derivative<br />
[[2ze9]] – SaPLD (mutant) + phosphatidylcholine<br />
[[1v0t]], [[1v0u]] – SaPLD + glycerophosphate<br />
[[6kz9]] – AtPLD a 1 – ''Arabidopsis thaliana''<br />
[[6kz8]] – AtPLD a 1 + phosphatidic acid <br />


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 11:40, 28 August 2023


Function

Phospholipase D (PLD) hydrolyzes phosphatidylcholine (PC) into phosphatidic acid and choline[1]. PLD is found in organisms ranging from virus to mammals.

Relevance

Dysregulation of lipid pathways is involved in many neurodegenerative disorders like Alzheimer disease. Brains of Alzheimer disease patients show decreased levels of PC and increased activity of PLD[2].

Structural highlights

The [3]. Water molecule are shown as red sphere.

3D structures of phospholipase D

Phospholipase D 3D structures


Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
  2. ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
  3. ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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