2c5c: Difference between revisions

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<StructureSection load='2c5c' size='340' side='right'caption='[[2c5c]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
<StructureSection load='2c5c' size='340' side='right'caption='[[2c5c]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c5c]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Bph30 Bph30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2C5C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c5c]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=S10:DIETHYL+PROPANE-1,3-DIYLBISCARBAMATE'>S10</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5c OCA], [http://pdbe.org/2c5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5c RCSB], [http://www.ebi.ac.uk/pdbsum/2c5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5c ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=S10:DIETHYL+PROPANE-1,3-DIYLBISCARBAMATE'>S10</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5c OCA], [https://pdbe.org/2c5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5c RCSB], [https://www.ebi.ac.uk/pdbsum/2c5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STXB_BPH19 STXB_BPH19]] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.  
[https://www.uniprot.org/uniprot/STXB_BPH30 STXB_BPH30] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Shiga toxin|Shiga toxin]]
*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bph30]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dodd, R B]]
[[Category: Phage h30]]
[[Category: Read, R J]]
[[Category: Dodd RB]]
[[Category: Bacterial exotoxin]]
[[Category: Read RJ]]
[[Category: Bivalent ligand]]
[[Category: Gb3 binding activity]]
[[Category: Ob fold]]
[[Category: Protein-carbohydrate recognition]]
[[Category: Toxin]]

Latest revision as of 17:06, 13 December 2023

Shiga-like toxin 1 B subunit complexed with a bivalent inhibitorShiga-like toxin 1 B subunit complexed with a bivalent inhibitor

Structural highlights

2c5c is a 10 chain structure with sequence from Phage h30. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.94Å
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STXB_BPH30 The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2c5c, resolution 2.94Å

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