7c7j: Difference between revisions

Latest revision as of 18:58, 29 November 2023

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Structural highlights

7c7j is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.39Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAP1B_HUMAN GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.^[1] ^[2]

References

↑ Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329. PMID:20332120 doi:10.1242/jcs.059329
↑ Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187

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OCA

[1] Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329. PMID:20332120 doi:10.1242/jcs.059329

[2] Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7c7j is ON HOLD  until Paper Publication
+==Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)==
+<StructureSection load='7c7j' size='340' side='right'caption='[[7c7j]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7c7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7j OCA], [https://pdbe.org/7c7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7j RCSB], [https://www.ebi.ac.uk/pdbsum/7c7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref>
-Authors:
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Pan LF]]
+[[Category: Xiao LX]]

7c7j: Difference between revisions

Latest revision as of 18:58, 29 November 2023

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Structural highlights

Function

See Also

References

Contents

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7c7j: Difference between revisions

Latest revision as of 18:58, 29 November 2023

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Structural highlights

Function

See Also

References

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