Nuclear receptor corepressor: Difference between revisions
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'''Nuclear receptor corepressors''' (N-CoR) and '''SMRT''' (Silencing Mediator of Retinoic acid and Thyroid hormone receptor) mediate the repression of gene subscription by nuclear receptors<ref>PMID:11845213</ref>. N-CoRs contain interaction domains with a conserved LXXII hydrophobic motif. This motif resembles the LXXLL motif of nuclear receptors<ref>PMID:11117528</ref>. | '''Nuclear receptor corepressors''' (N-CoR) and '''SMRT''' (Silencing Mediator of Retinoic acid and Thyroid hormone receptor) mediate the repression of gene subscription by nuclear receptors<ref>PMID:11845213</ref>. N-CoRs contain interaction domains with a conserved LXXII hydrophobic motif. This motif resembles the LXXLL motif of nuclear receptors<ref>PMID:11117528</ref>. | ||
*'''Nuclear receptor corepressor 1''' plays a role in repressing cardiac hypertrophy<ref>PMID:31532577</ref>. | |||
*'''Nuclear receptor corepressor 2''' is part of a multisubunit complex which modify chromatin structure. | |||
== Relevance == | == Relevance == | ||
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**[[2eqr]] – hN-CoR1 SANT1 domain 433-486 – human - NMR<br /> | **[[2eqr]] – hN-CoR1 SANT1 domain 433-486 – human - NMR<br /> | ||
**[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br /> | **[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br /> | ||
**[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA- | **[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA-α<br /> | ||
**[[5x8u]], [[5x8w]] – hN-CoR1 residues 686-700 + protein<br /> | **[[5x8u]], [[5x8w]] – hN-CoR1 residues 686-700 + protein<br /> | ||
**[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br /> | **[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br /> | ||