5n1x: Difference between revisions

<table><tr><td colspan='2'>[[5n1x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N1X FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HH:~{N}-ETHYL-5-PYRIDIN-3-YL-PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>8HH</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1x OCA], [http://pdbe.org/5n1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1x RCSB], [http://www.ebi.ac.uk/pdbsum/5n1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1x ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.  

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>

[[Category: Ferguson, A]]

[[Category: Hargreaves, D]]

[[Category: Robb, G]]

[[Category: Transferase]]