6xr0: Difference between revisions

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'''Unreleased structure'''


The entry 6xr0 is ON HOLD  until Paper Publication
==Crystal Structure of Human Melanotransferrin in complex with SC57.32 Fab==
<StructureSection load='6xr0' size='340' side='right'caption='[[6xr0]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6xr0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XR0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.064&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xr0 OCA], [https://pdbe.org/6xr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xr0 RCSB], [https://www.ebi.ac.uk/pdbsum/6xr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xr0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRFM_HUMAN TRFM_HUMAN] Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.<ref>PMID:7556058</ref>


Authors:  
==See Also==
 
*[[Melanoma-associated antigen|Melanoma-associated antigen]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Hayashi K]]
[[Category: Longenecker KL]]
[[Category: Vivona S]]

Latest revision as of 14:24, 30 October 2024

Crystal Structure of Human Melanotransferrin in complex with SC57.32 FabCrystal Structure of Human Melanotransferrin in complex with SC57.32 Fab

Structural highlights

6xr0 is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.064Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRFM_HUMAN Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.[1]

See Also

References

  1. ↑ Kennard ML, Richardson DR, Gabathuler R, Ponka P, Jefferies WA. A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 1995 Sep 1;14(17):4178-86. PMID:7556058 doi:10.1002/j.1460-2075.1995.tb00091.x

6xr0, resolution 3.06Å

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OCA
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