6zig: Difference between revisions

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'''Unreleased structure'''


The entry 6zig is ON HOLD  until Paper Publication
==Topological model of the p2 virion baseplate in activated conformation (closed Tal trimer)==
 
<StructureSection load='6zig' size='340' side='right'caption='[[6zig]], [[Resolution|resolution]] 42.20&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6zig]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_virus_P2 Lactococcus virus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZIG FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 42.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zig OCA], [https://pdbe.org/6zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zig RCSB], [https://www.ebi.ac.uk/pdbsum/6zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zig ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBP_BPLP2 RBP_BPLP2] Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.<ref>PMID:20351260</ref> <ref>PMID:24027307</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lactococcus virus P2]]
[[Category: Large Structures]]
[[Category: Cambillau C]]
[[Category: Goulet A]]
[[Category: Spinelli S]]

Latest revision as of 10:41, 1 May 2024

Topological model of the p2 virion baseplate in activated conformation (closed Tal trimer)Topological model of the p2 virion baseplate in activated conformation (closed Tal trimer)

Structural highlights

6zig is a 33 chain structure with sequence from Lactococcus virus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 42.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RBP_BPLP2 Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.[1] [2]

References

  1. ↑ Sciara G, Bebeacua C, Bron P, Tremblay D, Ortiz-Lombardia M, Lichiere J, van Heel M, Campanacci V, Moineau S, Cambillau C. Structure of lactococcal phage p2 baseplate and its mechanism of activation. Proc Natl Acad Sci U S A. 2010 Mar 29. PMID:20351260
  2. ↑ Bebeacua C, Tremblay D, Farenc C, Chapot-Chartier MP, Sadovskaya I, van Heel M, Veesler D, Moineau S, Cambillau C. Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2. J Virol. 2013 Nov;87(22):12302-12. PMID:24027307 doi:10.1128/JVI.02033-13

6zig, resolution 42.20Å

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OCA
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