6sm5: Difference between revisions

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-'''Unreleased structure'''
-The entry 6sm5 is ON HOLD  until Paper Publication
+==MbC/SHP1-C-SH2 complex==
+<StructureSection load='6sm5' size='340' side='right'caption='[[6sm5]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-Authors: Mann, G., Hantschel, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6sm5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SM5 FirstGlance]. <br>
-Description: MbC/SHP1-C-SH2 complex
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm5 OCA], [https://pdbe.org/6sm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6sm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm5 ProSAT]</span></td></tr>
-[[Category: Hantschel, O]]
+</table>
-[[Category: Mann, G]]
+== Function ==
+[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Hantschel O]]
+[[Category: Mann G]]