Dihydrofolate reductase 3D structures: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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 *DHFR-Thymidine synthase (TS) complex
+**[[6pfi]] - hDHFR-TS + NADPH + dUMP + pyrimidine derivative  <br />
 **[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br />
 **[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br />
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 **[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br />
 **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br />
-**[[3qg2]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br />
+**[[7ctw]], [[7cty]] - PfDHFR-TS +NADPH+ inhibitor<br />
+**[[3qg2]], [[6leu]], [[6lev]], [[6lez]], [[6lh9]], [[6lhi]], [[6lhj]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br />
 **[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br />
 **[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br />
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 **[[4or7]], [[4osg]], [[5ecc]], [[5ecx]] - DHFR +NADPH + pyrimidine derivative – ''Klebsiella pneumoniae'' <br />
 **[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br />
+**[[7k6c]] – DHFR (mutant) + NADPH + pyrimidine  derivative –'' Mycobacterioides abscessus''<br />
+**[[6uwq]], [[6uww]] – MuDHFR + NADPH + pyrimidine  derivative – ''Mycobacterium ulcerans''<br />
+**[[7k68]], [[7k6a]] – MuDHFR (mutant) + NADPH + pyrimidine  derivative <br />
 *''Ternary complexes with quinazoline derivative''
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 *''Ternary complexes with TMP''
+**[[2w3a]] – hDHFR +TMP+NADPH<BR />
+**[[1yho]] - hDHFR+NADPH+ TMP – NMR<BR />
+**[[2fzi]], [[2fzj]] - mDHFR+NADPH+ TMP<br />
 **[[2w9g]] - SaDHFR+ TMP +NADPH<BR />
 **[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR />
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 **[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br />
 **[[1lud]] - LcDHFR+NADPH+ TMP – NMR<BR />
-**[[2fzi]], [[2fzj]] - mDHFR+NADPH+ TMP<br />
+**[[2fzh]] – PcDHFR+NADPH+ TMP <br />
-**[[2fzh]] – PcDHFR+NADPH+ TMP <br />
-**[[2w3a]] – hDHFR +TMP+NADPH<BR />
-**[[1yho]] - hDHFR+NADPH+ TMP – NMR<BR />
 **[[1dg5]] - MtDHFR + TMP +NADPH<BR />
 **[[4km2]] - MtDHFR + ADP + TMP<br />
+**[[6xg4]], [[6xg5]] - EcDHFR+NADPH+ TMP<br />
 *''Ternary complexes with MTX''
 **[[1u71]], [[1u72]] - hDHFR (mutant)+MTX+NADPH<BR />
+**[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR />
 **[[3ia4]] – MpDHFR+ MTX +NADPH<BR />
 **[[3dat]] - BaDHFR+ MTX+NADPH<BR />
 **[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR />
-**[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR />
 **[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br />
 **[[1ddr]] - EcDHFR+MTX+urea<br />
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 **[[1vj3]] – PcHDFR+TAB+NADPH <br />
 **[[4m2x]] - MtDHFR + trimetrexate +NADPH<br />
-**[[6nnd]] - MtDHFR + DHF +NADPH<br />
 **[[6nnh]] - MtDHFR + cycloguanyl +NADPH<br />
 **[[6nni]] - MtDHFR + pyrimethamine +NADPH<br />
 **[[4kne]] - MtDHFR + ADP + anti-folate drug<br />
 **[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR />
+**[[6vs6]], [[6vs8]], [[6vs9]], [[6vsb]], [[6vsd]], [[6vse]], [[6vsf]], [[6vsg]] - MtDHFR + inhibitor +NADPH<BR />
 *DHFR higher complexes
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 *DHFR+ligands
-**[[2w3m]], [[4m6k]], [[6dav]] – hDHFR +folate+NADPH<BR />
+**[[2w3m]], [[4m6k]], [[6dav]], [[7ese]] – hDHFR +folate+NADPH<BR />
 **[[1drf]] - hDHFR +folate<br />
 **[[1dhf]], [[2dhf]] – hDHFR+folate+5-deazofolate<br />
 **[[4m6l]] - hDHFR+folate+ NADPH + folate derivative<br />
+**[[6vcj]] - hDHFR+folate+ NADPH + pyrimidine derivative + drug<br />
 **[[1e26]] - PcDHFR-TS+NADP+folate<br />
 **[[2jyb]] – HvDHFR+folate<br />
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 **[[7dfr]] - EcDHFR+NAP+NADP+folate<br />
 **[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br />
-**[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[1dyl]]  - EcDHFR+folate +NADP<br />
+**[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[1dyl]], [[7d3z]], [[7d49]], [[7d4l]], [[7d4x]], [[7d6g]], [[7lvc]] - EcDHFR+folate +NADP<br />
 **[[4pdj]] - EcDHFR+folate+NADP – Neutron<br />
 **[[5cc9]], [[5ccc]], [[1rc4]], [[1dyj]], [[1dyh]], [[1rx6]], [[6cyv]] - EcDHFR+folate derivative +NADP <br />
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 **[[3tqb]] – CbDHFR + NADPH + folate<br />
 **[[3frd]] – SaDHFR (mutant)+folate +NADP<br />
+**[[6nnd]] - MtDHFR + DHF +NADPH<br />
 *DHFR+co-factors
+**[[4m6j]] - hDHFR +NADPH<br />
+**[[8dfr]] - cDHFR +NADPH<BR />
 **[[2hqp]], [[2lf1]] – LcDHFR+NADPH – NMR<BR />
 **[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br />
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 **[[6dfr]] - EcDHFR+NAP+NADP<br />
 **[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR />
-**[[8dfr]] - cDHFR +NADPH<BR />
 **[[3tqa]] – CbDHFR + NADPH<br />
-**[[4m6j]] - hDHFR +NADPH<br />
 **[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br />
 **[[4m7u]] - EfDHFR +NADPH <br />