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<StructureSection load='6p8b' size='340' side='right'caption='[[6p8b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6p8b' size='340' side='right'caption='[[6p8b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6p8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P8B FirstGlance]. <br>
<table><tr><td colspan='2'>[[6p8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Phage_display_vector_pdvec0 Phage display vector pdvec0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P8B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O3V:3-hydroxy-7,7-dimethyl-2-phenyl-4-(thiophen-2-yl)-2,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one'>O3V</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxD, lpxD_1, lpxD_2, A8C65_17800, A9R57_04450, AC789_1c01770, ACN002_0184, ACN77_17005, ACN81_28485, ACU57_18525, ACU90_26495, AM270_18210, AML07_22885, AML35_22825, APZ14_11060, AUQ13_07450, AUS26_23195, AW059_09890, AW106_08805, B1K96_12940, B7C53_01310, BANRA_00558, BANRA_00653, BANRA_02262, BANRA_03350, BET08_19125, BHF46_07835, BHS81_00700, BHS87_00855, BIZ41_19025, BJJ90_21310, BK292_13720, BK400_03560, BMT53_09465, BN17_46021, BTQ06_06540, BUE81_01655, BVL39_02135, BW690_02415, BZL31_14885, C2U48_09555, C4J69_03380, C5N07_08630, C5P01_08975, C5P43_07335, C6669_04195, C6986_01145, C7235_20180, C7B06_05915, C7B07_04225, CA593_02815, CG691_14440, CG692_09445, CG705_12975, CG706_12690, COD30_14715, COD46_06685, CR538_20590, CR539_04985, CRM83_15040, CXB56_23080, D0X26_09365, D2184_08545, D2185_20180, D2F89_01460, D3821_06260, D3O91_03240, D3Y67_16455, D9D20_18680, D9D55_03030, D9D69_06830, D9E22_13300, D9E35_14480, D9G42_07535, D9H66_18155, D9H68_13825, D9I18_15010, D9I87_01590, D9I97_03755, D9J11_16875, D9J44_14030, DIV22_06320, DL545_20340, DMZ31_06810, DNQ41_04690, DNQ45_10065, DQF57_05615, DQO13_06200, DS732_05825, DTL43_05870, EAI42_08350, EAI46_03595, EAI52_11055, EC1094V2_3672, EC3234A_2c01610, EC3426_00931, EC382_03005, ECTO6_03883, ED287_04550, ED600_04595, EEP23_00115, EFV01_09910, EFV02_20465, EFV04_15215, EFV08_17150, EFV11_08135, EFV12_18845, EFV15_17225, EFV17_09875, EIA13_13600, EL75_3585, EL79_3695, EL80_3642, ERS085374_03841, ERS150873_01122, ERS150876_00054, FORC28_5013, HW43_04650, JD73_13090, NCTC10429_04183, NCTC10865_05054, NCTC11022_04906, NCTC11126_03647, NCTC13462_02218, NCTC8500_04533, NCTC8960_01551, NCTC9037_04178, NCTC9045_04699, NCTC9055_00956, NCTC9058_02808, NCTC9062_04225, NCTC9706_01326, NCTC9969_04255, PU06_22990, RG28_03860, RK56_027945, RX35_04913, SAMEA3472043_02537, SAMEA3472044_04146, SAMEA3472047_02509, SAMEA3472070_02384, SAMEA3472080_03763, SAMEA3472114_03609, SAMEA3484427_01386, SAMEA3484429_01095, SAMEA3752553_02884, SAMEA3752557_00885, SAMEA3752559_03701, SAMEA3753064_03381, SAMEA3753097_03916, SAMEA3753290_00404, SAMEA3753300_01852, SK85_00179, WQ89_09605, WR15_02380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O3V:3-hydroxy-7,7-dimethyl-2-phenyl-4-(thiophen-2-yl)-2,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one'>O3V</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-(3-hydroxymyristoyl)glucosamine_N-acyltransferase UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.191 2.3.1.191] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8b OCA], [https://pdbe.org/6p8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p8b RCSB], [https://www.ebi.ac.uk/pdbsum/6p8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8b OCA], [http://pdbe.org/6p8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p8b RCSB], [http://www.ebi.ac.uk/pdbsum/6p8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q0P6M7_ECOLX Q0P6M7_ECOLX]] Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.[HAMAP-Rule:MF_00523]
[https://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6p8b" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6p8b" style="background-color:#fffaf0;"></div>
==See Also==
*[[UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase|UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ma, X]]
[[Category: Phage display vector pdvec0]]
[[Category: Shia, S]]
[[Category: Ma X]]
[[Category: Lps synthesis]]
[[Category: Shia S]]
[[Category: Transferase]]
[[Category: Transferase-inhibitor complex]]

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