1duq: Difference between revisions

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New page: left|200px<br /> <applet load="1duq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1duq, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1duq.gif|left|200px]]<br />
<applet load="1duq" size="450" color="white" frame="true" align="right" spinBox="true"
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'''CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1'''<br />


==Overview==
==CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1==
The crystal and molecular structure of an RNA duplex corresponding to the, high affinity Rev protein binding element (RBE) has been determined at, 2.1-A resolution. Four unique duplexes are present in the crystal, comprising two structural variants. In each duplex, the RNA double helix, consists of an annealed 12-mer and 14-mer that form an asymmetric internal, loop consisting of G-G and G-A noncanonical base pairs and a flipped-out, uridine. The 12-mer strand has an A-form conformation, whereas the 14-mer, strand is distorted to accommodate the bulges and noncanonical base, pairing. In contrast to the NMR model of the unbound RBE, an asymmetric, G-G pair with N2-N7 and N1-O6 hydrogen bonding, is formed in each helix., The G-A base pairing agrees with the NMR structure in one structural, variant, but forms a novel water-mediated pair in the other. A backbone, flip and reorientation of the G-G base pair is required to assume the RBE, conformation present in the NMR model of the complex between the RBE and, the Rev peptide.
<StructureSection load='1duq' size='340' side='right'caption='[[1duq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1duq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUQ FirstGlance]. <br>
1DUQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DUQ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1duq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1duq OCA], [https://pdbe.org/1duq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1duq RCSB], [https://www.ebi.ac.uk/pdbsum/1duq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1duq ProSAT]</span></td></tr>
The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability., Hung LW, Holbrook EL, Holbrook SR, Proc Natl Acad Sci U S A. 2000 May 9;97(10):5107-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10792052 10792052]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Holbrook, E.L.]]
</StructureSection>
[[Category: Holbrook, S.R.]]
[[Category: Large Structures]]
[[Category: Hung, L.W.]]
[[Category: Holbrook EL]]
[[Category: NA]]
[[Category: Holbrook SR]]
[[Category: hiv-1]]
[[Category: Hung L-W]]
[[Category: rev binding domain]]
[[Category: rre]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 13:59:15 2007''

Latest revision as of 09:59, 7 February 2024

CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1

Structural highlights

1duq is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1duq, resolution 2.10Å

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