2v8x: Difference between revisions

<table><tr><td colspan='2'>[[2v8x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V8X FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGQ:7-BENZYL+GUANINE+MONOPHOSPHATE'>MGQ</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8x OCA], [https://pdbe.org/2v8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v8x RCSB], [https://www.ebi.ac.uk/pdbsum/2v8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v8x ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>  

[[Category: Homo sapiens]]

[[Category: Brown CJ]]

[[Category: Fischer PM]]

[[Category: Mcnae I]]

[[Category: Walkinshaw MD]]