5rk5: Difference between revisions

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'''Unreleased structure'''


The entry 5rk5 is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z57478994==
<StructureSection load='5rk5' size='340' side='right'caption='[[5rk5]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5rk5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RK5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.243&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UVS:5-(methoxymethyl)-1,3,4-thiadiazol-2-amine'>UVS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rk5 OCA], [https://pdbe.org/5rk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rk5 RCSB], [https://www.ebi.ac.uk/pdbsum/5rk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rk5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref>


Authors: Grosjean, H., Aimon, A., Krojer, T., Talon, R., Douangamath, A., Koekemoer, L., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Biggin, P.C.
==See Also==
 
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
Description: PanDDA analysis group deposition --Crystal Structure of PHIP in complex with Z57478994
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Aimon, A]]
__TOC__
[[Category: Grosjean, H]]
</StructureSection>
[[Category: Biggin, P.C]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.H]]
[[Category: Large Structures]]
[[Category: Talon, R]]
[[Category: Aimon A]]
[[Category: Edwards, A]]
[[Category: Arrowsmith CH]]
[[Category: Douangamath, A]]
[[Category: Biggin PC]]
[[Category: Krojer, T]]
[[Category: Bountra C]]
[[Category: Von Delft, F]]
[[Category: Douangamath A]]
[[Category: Bountra, C]]
[[Category: Edwards A]]
[[Category: Koekemoer, L]]
[[Category: Grosjean H]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: Talon R]]
[[Category: Von Delft F]]

Latest revision as of 16:51, 1 March 2024

PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z57478994PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z57478994

Structural highlights

5rk5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.243Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PHIP_HUMAN Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2]

See Also

References

  1. ↑ Farhang-Fallah J, Randhawa VK, Nimnual A, Klip A, Bar-Sagi D, Rozakis-Adcock M. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol. 2002 Oct;22(20):7325-36. PMID:12242307
  2. ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54

5rk5, resolution 1.24Å

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