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==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z285642082== | |||
<StructureSection load='5rjs' size='340' side='right'caption='[[5rjs]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5rjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RJS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UUP:N-cyclopropylpyrazolo[1,5-a]pyrimidine-3-carboxamide'>UUP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rjs OCA], [https://pdbe.org/5rjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rjs RCSB], [https://www.ebi.ac.uk/pdbsum/5rjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rjs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | |||
==See Also== | |||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Aimon | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Biggin | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Aimon A]] | ||
[[Category: Edwards | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Biggin PC]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Douangamath A]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: | [[Category: Grosjean H]] | ||
[[Category: Koekemoer L]] | |||
[[Category: Krojer T]] | |||
[[Category: Talon R]] | |||
[[Category: Von Delft F]] | |||