7c3y: Difference between revisions
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New page: '''Unreleased structure''' The entry 7c3y is ON HOLD Authors: Su, Z.D., Cheng, X.Y., Zhang, B.L., Kuang, Z.K., Yang, J., Li, Z.C., Yu, J.P., Zhao, Z.T., Cao, C.Z. Description: Crystal ... |
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==Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a== | |||
<StructureSection load='7c3y' size='340' side='right'caption='[[7c3y]], [[Resolution|resolution]] 1.63Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7c3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C3Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.632Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c3y OCA], [https://pdbe.org/7c3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c3y RCSB], [https://www.ebi.ac.uk/pdbsum/7c3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c3y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | |||
==See Also== | |||
*[[MDM4|MDM4]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cao CZ]] | ||
[[Category: | [[Category: Cheng XY]] | ||
[[Category: | [[Category: Kuang ZK]] | ||
[[Category: Zhang | [[Category: Li ZC]] | ||
[[Category: | [[Category: Su ZD]] | ||
[[Category: Yang J]] | |||
[[Category: Yu JP]] | |||
[[Category: Zhang BL]] | |||
[[Category: Zhao ZT]] | |||
Latest revision as of 18:55, 29 November 2023
Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3aCrystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
Structural highlights
FunctionMDM4_HUMAN Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.[1] [2] See AlsoReferences
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