CD81: Difference between revisions
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<StructureSection load=' | <StructureSection load='6u9s' size='400' side='right' caption='Human CD81 (magenta) complex with mouse antibody heavy chain (cyan), light chain (green) and glycerol (PDB code [[6u9s]])' scene='84/845937/Cv/2'> | ||
== Function == | == Function == | ||
CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation | CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells<ref>PMID:9597125</ref>. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins. CD81 enables hepatitis C virus infection of human cells<ref>PMID:20004001</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The structure of the <scene name='84/845937/Cv/5'>complex of human CD81 with mouse antibody</scene> shows <scene name='84/845937/Cv/4'>interactions</scene> of the CD81 helix D with the antibody heavy chain and CD81 residues in helix C with the light chain<ref>PMID:32338599</ref>. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of CD81== | ==3D structures of CD81== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[5tcx]] - hCD81 (mutant) - human<br /> | [[5tcx]] - hCD81 (mutant) - human<br /> | ||
[[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e | [[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e]] - hCD81 extracellular domain 113-202<br /> | ||
[[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br /> | [[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br /> | ||
[[5dfv]] - hCD81 extracellular domain + antibody<br /> | [[5dfv]], [[6u9s]] - hCD81 extracellular domain + antibody<br /> | ||
[[ | [[7jic]] - hCD81 extracellular domain + CD19 + antibody – Cryo EM<br /> | ||
[[ | [[3x0g]] - CD81 extracellular domain - green monkey<br /> | ||
[[3x0f]] - CD81 extracellular domain - mouse<br /> | |||
[[7mws]] - cttCD81 112-202 – cotton-top tamarin<br /> | |||
[[7mwx]] - cttCD81 second extracellular domain + antibody + hepatitis virus core <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||