CD81: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='6u9s' size='400' side='right' caption='Human CD81 (magenta) complex with mouse antibody heavy chain (cyan), light chain (green) and glycerol (PDB code [[6u9s]])' scene='84/845937/Cv/2'>
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
-== Disease ==
+CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells<ref>PMID:9597125</ref>.  CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins.  CD81 enables hepatitis C virus infection of human cells<ref>PMID:20004001</ref>.
 == Relevance ==
+CD81 is widely expressed on the majority of tumor cells.  Antibodies that target CD81 are a novel treatment against B-cell lymphoma<ref>PMID:31123084</ref>.  CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response.
 == Structural highlights ==
+The structure of the <scene name='84/845937/Cv/5'>complex of human CD81 with mouse antibody</scene> shows <scene name='84/845937/Cv/4'>interactions</scene> of the CD81 helix D with the antibody heavy chain and CD81 residues in helix C with the light chain<ref>PMID:32338599</ref>.
 </StructureSection>
 ==3D structures of CD81==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1g8q]] - hCD81 extracellular domain 113-202 - human<br />
+[[5tcx]] - hCD81 (mutant) - human<br />
-[[3k0g]] - CD81 extracellular domain - green monkey<br />
+[[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e]] - hCD81 extracellular domain 113-202<br />
+[[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br />
+[[5dfv]], [[6u9s]] - hCD81 extracellular domain + antibody<br />
+[[7jic]] - hCD81 extracellular domain + CD19 + antibody – Cryo EM<br />
+[[3x0g]] - CD81 extracellular domain - green monkey<br />
+[[3x0f]] - CD81 extracellular domain - mouse<br />
+[[7mws]] - cttCD81 112-202 – cotton-top tamarin<br />
+[[7mwx]] - cttCD81 second extracellular domain + antibody + hepatitis virus core <br />
 == References ==
 <references/>
+[[Category:Topic Page]]