5fnr: Difference between revisions

<table><tr><td colspan='2'>[[5fnr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FNR FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XMS:(3S)-3-(4-CHLOROPHENYL)-3-(1-METHYLBENZOTRIAZOL-5-YL)PROPANOIC+ACID'>XMS</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnr OCA], [https://pdbe.org/5fnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fnr RCSB], [https://www.ebi.ac.uk/pdbsum/5fnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnr ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>  

[[Category: Mus musculus]]

[[Category: Bolognese BJ]]

[[Category: Callahan JF]]

[[Category: Cottom JE]]

[[Category: Coyle JE]]

[[Category: Davies TG]]

[[Category: Feldser HG]]

[[Category: Foley JP]]

[[Category: Griffiths-Jones C]]

[[Category: Hearn K]]

[[Category: Heightman TD]]

[[Category: Kerns JK]]

[[Category: Kou J]]

[[Category: Logan G]]

[[Category: McMenamin R]]

[[Category: Norton D]]

[[Category: Podolin PL]]

[[Category: Rich SJ]]

[[Category: Richardson C]]

[[Category: Sanchez Y]]

[[Category: Saxty G]]

[[Category: Willems HMG]]

[[Category: Wixted WE]]

[[Category: Woolford AJ]]

[[Category: Yan H]]

[[Category: Yonchuk JG]]