6wor: Difference between revisions
New page: '''Unreleased structure''' The entry 6wor is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures |
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The entry | ==Structure of the broadly neutralizing antibody HC1AM== | ||
<StructureSection load='6wor' size='340' side='right'caption='[[6wor]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6wor]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WOR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wor OCA], [https://pdbe.org/6wor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wor RCSB], [https://www.ebi.ac.uk/pdbsum/6wor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wor ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bind to the "neutralizing face" on E2, including several broadly nAbs encoded by the VH1-69 germline gene family that bind to a similar conformation (A) of this face. Here, a previously unknown conformation (B) of the neutralizing face is revealed in crystal structures of two of four additional E2-VH1-69 nAb complexes. In this conformation, the E2 front-layer region is displaced upon antibody binding, exposing residues in the back layer for direct antibody interaction. This E2 B structure may represent another conformational state in the viral entry process that is susceptible to antibody neutralization and thus provide a new target for rational vaccine development. | |||
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target.,Tzarum N, Giang E, Kadam RU, Chen F, Nagy K, Augestad EH, Velazquez-Moctezuma R, Keck ZY, Hua Y, Stanfield RL, Dreux M, Prentoe J, Foung SKH, Bukh J, Wilson IA, Law M Sci Adv. 2020 Jul 24;6(30):eabb5642. doi: 10.1126/sciadv.abb5642. eCollection, 2020 Jul. PMID:32754640<ref>PMID:32754640</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6wor" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Law M]] | |||
[[Category: Tzarum N]] | |||
[[Category: Wilson IA]] | |||