6wl4: Difference between revisions

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-'''Unreleased structure'''
-The entry 6wl4 is ON HOLD
+==preTCRbeta-pMHC complex crystal structure==
+<StructureSection load='6wl4' size='340' side='right'caption='[[6wl4]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6wl4]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WL4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wl4 OCA], [https://pdbe.org/6wl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6wl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wl4 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Self-discrimination, a critical but ill-defined molecular process programmed during thymocyte development, requires myriad pre-T cell receptors (preTCRs) and alphabetaTCRs. Using x-ray crystallography, we show how a preTCR applies the concave beta-sheet surface of its single variable domain (Vbeta) to "horizontally" grab the protruding MHC alpha2-helix. By contrast, alphabetaTCRs purpose all six complementarity-determining region (CDR) loops of their paired ValphaVbeta module to recognize peptides bound to major histocompatibility complex molecules (pMHCs) in "vertical" head-to-head binding. The preTCR topological fit ensures that CDR3beta reaches the peptide's featured C-terminal segment for pMHC sampling, establishing the subsequent alphabetaTCR canonical docking mode. "Horizontal" docking precludes germline CDR1beta- and CDR2beta-MHC binding to broaden beta-chain repertoire diversification before alphabetaTCR-mediated selection refinement. Thus, one subunit successively attunes the recognition logic of related multicomponent receptors.
-Authors: Li, X., Mallis, R.J., Mizsei, R., Tan, K., Reinherz, E.L., Wang, J.
+Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.,Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL Science. 2021 Jan 8;371(6525):181-185. doi: 10.1126/science.abe0918. Epub 2020 , Dec 17. PMID:33335016<ref>PMID:33335016</ref>
-Description: preTCRbeta-pMHC complex crystal structure
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Mizsei, R]]
+<div class="pdbe-citations 6wl4" style="background-color:#fffaf0;"></div>
-[[Category: Tan, K]]
-[[Category: Wang, J]]
+==See Also==
-[[Category: Mallis, R.J]]
+*[[MHC 3D structures|MHC 3D structures]]
-[[Category: Li, X]]
+*[[MHC I 3D structures|MHC I 3D structures]]
-[[Category: Reinherz, E.L]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Vesicular stomatitis virus]]
+[[Category: Li X]]
+[[Category: Mallis RJ]]
+[[Category: Mizsei R]]
+[[Category: Reinherz EL]]
+[[Category: Tan K]]
+[[Category: Wang J]]