4bil: Difference between revisions
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<SX load='4bil' size='340' side='right' viewer='molstar' caption='[[4bil]], [[Resolution|resolution]] 29.00Å' scene=''> | <SX load='4bil' size='340' side='right' viewer='molstar' caption='[[4bil]], [[Resolution|resolution]] 29.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bil]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bil]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 29Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bil OCA], [https://pdbe.org/4bil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bil RCSB], [https://www.ebi.ac.uk/pdbsum/4bil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bil ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TERL_BPT7 TERL_BPT7] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome at a unique and precise dsDNA sequence to initiate and to end a packaging reaction (By similarity). The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (By similarity). Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine (PubMed:23632014). The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer (By similarity). Once the DNA is packaged, the terminase detaches from the portal and gets replaced by the tail to finish maturation of the virion (PubMed:23632014).[HAMAP-Rule:MF_04147]<ref>PMID:23632014</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Terminase|Terminase]] | *[[Terminase 3D Structures|Terminase 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
[[Category: | [[Category: Escherichia phage T7]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carrascosa | [[Category: Carrascosa JL]] | ||
[[Category: Dauden | [[Category: Dauden MI]] | ||
[[Category: Martin-Benito | [[Category: Martin-Benito J]] | ||
[[Category: Pulido-Cid | [[Category: Pulido-Cid M]] | ||
[[Category: Sanchez-Ferrero | [[Category: Sanchez-Ferrero JC]] | ||
[[Category: Valpuesta | [[Category: Valpuesta JM]] | ||