Furin: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processi... |
Michal Harel (talk | contribs) No edit summary |
||
| (4 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='6eqv' size='340' side='right' caption='Human furin complex with peptide inhibitor, Ca++ (green), Na+ (purple), citrulline, phenylacetaldehyde and aminoetyl-benzenecarboximiidamide (PDB [[6eqv]])' scene=''> | |||
<StructureSection load=' | __TOC__ | ||
== Function == | |||
== Function | |||
'''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | ||
| Line 8: | Line 7: | ||
== Relevance == | == Relevance == | ||
High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. | High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. See [[SARS-CoV-2 protein S priming by furin]], an animation. | ||
== Structural highlights == | <!--== Structural highlights == --> | ||
</StructureSection> | </StructureSection> | ||
| Line 18: | Line 17: | ||
[[5jxg]], [[5jxi]] - hFur - human<br /> | [[5jxg]], [[5jxi]] - hFur - human<br /> | ||
[[6eqx]], [[6eqw]], [[6eqv]], [[5jxh]], [[5jxj]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]] - hFur + peptide inhibitor<br /> | [[4z2a]] - hFur (mutant)<br /> | ||
[[5mim]] - hFur + inhibitor<br /> | [[6eqx]], [[6eqw]], [[6eqv]], [[5jxh]], [[5jxj]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[4ryd]], [[4omc]], [[5omd]] - hFur + peptide inhibitor<br /> | ||
[[5mim]], [[6yd2]], [[6yd3]], [[6yd4]], [[6yd7]] - hFur + inhibitor<br /> | |||
[[5jmo]] - hFur + antibody<br /> | |||
[[1p8j]] - mFur + peptide inhibitor - mouse<br /> | [[1p8j]] - mFur + peptide inhibitor - mouse<br /> | ||