7bp4: Difference between revisions

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'''Unreleased structure'''


The entry 7bp4 is ON HOLD
==Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)==
 
<StructureSection load='7bp4' size='340' side='right'caption='[[7bp4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Luo, Q., Baihui, W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7bp4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BP4 FirstGlance]. <br>
Description: Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Luo, Q]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bp4 OCA], [https://pdbe.org/7bp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bp4 RCSB], [https://www.ebi.ac.uk/pdbsum/7bp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bp4 ProSAT]</span></td></tr>
[[Category: Baihui, W]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/H2A6_ARATH H2A6_ARATH] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for the T-DNA integration step of plant transformation by Agrobacterium. May play an important role in illegitimate recombination.<ref>PMID:10639185</ref> <ref>PMID:12410808</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baihui W]]
[[Category: Luo Q]]

Latest revision as of 13:48, 27 March 2024

Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)

Structural highlights

7bp4 is a 6 chain structure with sequence from Arabidopsis thaliana and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H2A6_ARATH Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for the T-DNA integration step of plant transformation by Agrobacterium. May play an important role in illegitimate recombination.[1] [2]

References

  1. ↑ Mysore KS, Nam J, Gelvin SB. An Arabidopsis histone H2A mutant is deficient in Agrobacterium T-DNA integration. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):948-53. PMID:10639185 doi:10.1073/pnas.97.2.948
  2. ↑ Yi H, Mysore KS, Gelvin SB. Expression of the Arabidopsis histone H2A-1 gene correlates with susceptibility to Agrobacterium transformation. Plant J. 2002 Nov;32(3):285-98. PMID:12410808 doi:10.1046/j.1365-313x.2002.01425.x

7bp4, resolution 2.10Å

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OCA
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