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| *'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes. | | *'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes. |
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| | *'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br /> |
| | *'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br /> |
| | *'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br /> |
| | *'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br /> |
| | *'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br /> |
| | *'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation. <br /> |
| | *'''WD repeat protein CSA''' or '''DNA excision repair protein ERCC-8''' is part of the transcription-coupled repair complex<ref>PMID:32355176</ref>. <br /> |
| == Disease == | | == Disease == |
| Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>. | | Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>. |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres. | | The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres. |
| | | == 3D Structures of WD-repeat protein == |
| | [[WD-repeat protein 3D structures]] |
| </StructureSection> | | </StructureSection> |
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| == 3D Structures of WD-repeat protein ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *WDR5
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| **[[2gnq]], [[2h68]], [[2h14]], [[2h9l]] – hWDR5 – human<br />
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| **[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br />
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| **[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br />
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| **[[6u5m]], [[6u5y]], [[6u6w]], [[6u80]], [[6u8b]], [[6u8l]], [[6u8o]] – hWDR5 + sulfonamide inhibitor<br />
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| **[[6ufx]], [[6ucs]], [[6pg3]], [[6pg4]], [[6pg5]], [[6pg6]], [[6pg7]], [[6pg8]], [[6pg9]], [[6pga]], [[6pgb]], [[6pgc]], [[6pgd]], [[6pge]], [[6pgf]], [[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]], [[6e1z]], [[6e1y]], [[6e22]], [[6e23]] – hWDR5 + inhibitor<br />
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| **[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br />
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| **[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br />
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| **[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br />
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| **[[4o45]] – hWDR5 + influenza NS1 C-terminal<br />
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| **[[4cy1]] – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides<br />
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| **[[4cy2]] – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide<br />
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| **[[4y7r]] – hWDR5 + Myc MbIIIb peptide<br />
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| **[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br />
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| **[[4erz]] – hWDR5 + MLL4<br />
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| **[[6kiv]], [[6kiz]], [[6kiu]], [[6kix]] – hWDR5 in MLL1-ubNCP complex - Cryo EM<br />
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| **[[6kiw]] – hWDR5 in MLL3-ubNCP complex - Cryo EM<br />
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| **[[6pww]], [[6pwv]] – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM<br />
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| **[[6byn]] – hWDR5 + monobody<br />
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| **[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br />
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| **[[6iam]] – hWDR5 + small ubiquitin-related modifier 5<br />
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| *WDR9
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| **[[2q2e]] – hWDR9 residues 1310-1430<br />
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| *WDR12
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| **[[6p0q]] – hWDR12 UBL domain residues 1-87<br />
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| **[[6n31]] – hWDR12 residues 90-422<br />
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| *WDR20
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| **[[5k19]] – hWDR20<br />
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| *WDR33 or pre-mRNA 3' end processing protein WDR33
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| **[[6f9n]] – hWDR33 residues 35-410 + CPSF160<br />
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| **[[6urg]] – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM<br />
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| **[[6fbs]], [[6fuw]], [[6uro]] – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM<br />
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| *WDR48
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| **[[5cvl]] – hWDR48 <br />
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| **[[5l8e]] – hWDR48 + peptide<br />
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| **[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br />
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| **[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br />
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| **[[5k1c]], [[6jlq]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br />
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| *WDR60
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| **[[6rlb]], [[6sc2]] – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM<br />
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| *WDR61
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| **[[3ow8]] – hWDR61<br />
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| *WDR91
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| **[[6vyc]] – hWDR91 residues 392-747<br />
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| *WDR92
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| **[[3i2n]] – hWDR92<br />
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| *WDR SLP1
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| **[[4aez]] – WDR + mitotic spindle checkpoint component mad2-mad3 - fission yeast <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |