6w2h: Difference between revisions

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-'''Unreleased structure'''
-The entry 6w2h is ON HOLD
+==Crystal Structure of the Internal UBA Domain of HHR23A==
+<StructureSection load='6w2h' size='340' side='right'caption='[[6w2h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6w2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W2H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2h OCA], [https://pdbe.org/6w2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w2h RCSB], [https://www.ebi.ac.uk/pdbsum/6w2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RD23A_HUMAN RD23A_HUMAN] Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref>   Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref>   Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref>
-Authors: Bowler, B.E., Zeng, B., Becht, D.C., Rothfuss, M., Sprang, S.R., Mou, T.-C.
+==See Also==
+*[[UV excision repair protein 3D structures|UV excision repair protein 3D structures]]
-Description: Crystal Structure of the Internal UBA Domain of HHR23A
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zeng, B]]
+__TOC__
-[[Category: Bowler, B.E]]
+</StructureSection>
-[[Category: Mou, T.-C]]
+[[Category: Homo sapiens]]
-[[Category: Becht, D.C]]
+[[Category: Large Structures]]
-[[Category: Rothfuss, M]]
+[[Category: Becht DC]]
-[[Category: Sprang, S.R]]
+[[Category: Bowler BE]]
+[[Category: Mou T-C]]
+[[Category: Rothfuss M]]
+[[Category: Sprang SR]]
+[[Category: Zeng B]]