6u7h: Difference between revisions

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OCA

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 <SX load='6u7h' size='340' side='right' viewer='molstar' caption='[[6u7h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6u7h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvh22 Cvh22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U7H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6u7h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U7H FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u7h OCA], [http://pdbe.org/6u7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u7h RCSB], [http://www.ebi.ac.uk/pdbsum/6u7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u7h ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u7h OCA], [https://pdbe.org/6u7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u7h RCSB], [https://www.ebi.ac.uk/pdbsum/6u7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u7h ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 6u7h" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Sandbox 3001|Sandbox 3001]]
+*[[Spike protein 3D structures|Spike protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </SX>
-[[Category: Cvh22]]
+[[Category: Human coronavirus 229E]]
 [[Category: Large Structures]]
-[[Category: Benlekbir, S]]
+[[Category: Benlekbir S]]
-[[Category: Li, Z]]
+[[Category: Li Z]]
-[[Category: Rini, J M]]
+[[Category: Rini JM]]
-[[Category: Rubinstein, J L]]
+[[Category: Rubinstein JL]]
-[[Category: Apn]]
-[[Category: Cov coronavirus 229e]]
-[[Category: Spike glycoprotein]]
-[[Category: Viral protein]]