1hbi: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1hbi.gif|left|200px]]<br />
-<applet load="1hbi" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1hbi, resolution 1.7&Aring;" />
-'''CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION==
-The crystal structure of the cooperative dimeric hemoglobin from the blood, clam Scapharca inaequivalvis has been determined in the oxygenated state, and refined to an R-factor of 0.157 at 1.7-A resolution. The structure is, very similar to the carbon monoxide-liganded form with subtle differences, in ligand binding geometry. Oxygen binds to the heme iron in a bent, conformation with Fe-O-O angles of 135 degrees and 150 degrees for the two, subunits. These observed angles are lower than the equivalent angles in, the carbon monoxide-liganded form and intermediate between the angles, observed in structures of oxygenated sperm whale myoglobin and oxygenated, human hemoglobin. This third high resolution structure of Scapharca, dimeric hemoglobin permits a detailed analysis of the water structure in, the highly hydrated interface between subunits.
+<StructureSection load='1hbi' size='340' side='right'caption='[[1hbi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1hbi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HBI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hbi OCA], [https://pdbe.org/1hbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hbi RCSB], [https://www.ebi.ac.uk/pdbsum/1hbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hbi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/1hbi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hbi ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-HBI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis] with HEM and OXY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HBI OCA].
+*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution., Condon PJ, Royer WE Jr, J Biol Chem. 1994 Oct 14;269(41):25259-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7929217 7929217]
+[[Category: Anadara inaequivalvis]]
-[[Category: Scapharca inaequivalvis]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Condon PJ]]
-[[Category: Condon, P.J.]]
+[[Category: Royer Junior WE]]
-[[Category: Junior, W.E.Royer.]]
-[[Category: HEM]]
-[[Category: OXY]]
-[[Category: oxygen transport]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 13:04:20 2007''