5uow: Difference between revisions

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 <SX load='5uow' size='340' side='right' viewer='molstar' caption='[[5uow]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5uow]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5uow]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UOW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMK:(5S,10R)-5-METHYL-10,11-DIHYDRO-5H-5,10-EPIMINODIBENZO[A,D][7]ANNULENE'>BMK</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMK:(5S,10R)-5-METHYL-10,11-DIHYDRO-5H-5,10-EPIMINODIBENZO[A,D][7]ANNULENE'>BMK</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5up2|5up2]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uow OCA], [https://pdbe.org/5uow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uow RCSB], [https://www.ebi.ac.uk/pdbsum/5uow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uow ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LOC100127346 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), NR2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uow OCA], [http://pdbe.org/5uow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uow RCSB], [http://www.ebi.ac.uk/pdbsum/5uow PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uow ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NMDE1_XENLA NMDE1_XENLA] Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in dendritic branching in brain neurons and in synaptic plasticity (PubMed:18216193). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity).[UniProtKB:P35436]<ref>PMID:18216193</ref> <ref>PMID:28232581</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </SX>
-[[Category: African clawed frog]]
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Du, J]]
+[[Category: Xenopus laevis]]
-[[Category: Goehring, A]]
+[[Category: Du J]]
-[[Category: Gouaux, E]]
+[[Category: Goehring A]]
-[[Category: Lu, W]]
+[[Category: Gouaux E]]
-[[Category: Membrane protein]]
+[[Category: Lu W]]