2bk1: Difference between revisions

<table><tr><td colspan='2'>[[2bk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BK1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 29&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk1 OCA], [https://pdbe.org/2bk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bk1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk1 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref>  

[[Category: Clostridium perfringens]]

[[Category: Andrew PW]]

[[Category: Gilbert RJC]]

[[Category: Orlova EV]]

[[Category: Saibil HR]]

[[Category: Tilley SJ]]