6uft: Difference between revisions

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<StructureSection load='6uft' size='340' side='right'caption='[[6uft]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6uft' size='340' side='right'caption='[[6uft]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6uft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFT FirstGlance]. <br>
<table><tr><td colspan='2'>[[6uft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UFT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9000814&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uft OCA], [http://pdbe.org/6uft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uft RCSB], [http://www.ebi.ac.uk/pdbsum/6uft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uft ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uft OCA], [https://pdbe.org/6uft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uft RCSB], [https://www.ebi.ac.uk/pdbsum/6uft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uft ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
==See Also==
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jin, R]]
[[Category: Vicugna pacos]]
[[Category: Lam, K]]
[[Category: Jin R]]
[[Category: Antitoxin]]
[[Category: Lam K]]
[[Category: Receptor-binding domain]]
[[Category: Toxin]]
[[Category: Toxin-antitoxin complex]]
[[Category: Vhh]]

Latest revision as of 11:23, 17 October 2024

Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12

Structural highlights

6uft is a 2 chain structure with sequence from Clostridium botulinum and Vicugna pacos. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9000814Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

6uft, resolution 2.90Å

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