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| ==Human telomere DNA two-tetrad quadruplex structure in K+ solution== | | ==Human telomere DNA two-tetrad quadruplex structure in K+ solution== |
| <StructureSection load='2kka' size='340' side='right'caption='[[2kka]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''> | | <StructureSection load='2kka' size='340' side='right'caption='[[2kka]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKA FirstGlance]. <br> | | <table><tr><td colspan='2'>[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKA FirstGlance]. <br> |
| </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hy9|2hy9]], [[2jpz|2jpz]]</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kka OCA], [https://pdbe.org/2kka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kka RCSB], [https://www.ebi.ac.uk/pdbsum/2kka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kka ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kka OCA], [http://pdbe.org/2kka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kka RCSB], [http://www.ebi.ac.uk/pdbsum/2kka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kka ProSAT]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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| Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures.,Zhang Z, Dai J, Veliath E, Jones RA, Yang D Nucleic Acids Res. 2010 Jan;38(3):1009-21. Epub 2009 Nov 27. PMID:19946019<ref>PMID:19946019</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2kka" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Dai, J]] | | [[Category: Dai J]] |
| [[Category: Yang, D]] | | [[Category: Yang D]] |
| [[Category: Zhang, Z]] | | [[Category: Zhang Z]] |
| [[Category: Dna]]
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| [[Category: Human telomere g-quadruplex]]
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