1akm: Difference between revisions

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[[Image:1akm.gif|left|200px]]


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==ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI==
The line below this paragraph, containing "STRUCTURE_1akm", creates the "Structure Box" on the page.
<StructureSection load='1akm' size='340' side='right'caption='[[1akm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1akm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akm OCA], [https://pdbe.org/1akm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akm RCSB], [https://www.ebi.ac.uk/pdbsum/1akm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akm ProSAT]</span></td></tr>
{{STRUCTURE_1akm| PDB=1akm |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/OTC1_ECOLI OTC1_ECOLI] Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.<ref>PMID:3072022</ref> <ref>PMID:789338</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/1akm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1akm ConSurf].
<div style="clear:both"></div>


'''ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI'''
==See Also==
 
*[[Ornithine carbamoyltransferase 3D structures|Ornithine carbamoyltransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
1AKM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKM OCA].
__TOC__
 
</StructureSection>
==Reference==
Crystal structure at 2.8 A resolution of anabolic ornithine transcarbamylase from Escherichia coli., Jin L, Seaton BA, Head JF, Nat Struct Biol. 1997 Aug;4(8):622-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253409 9253409]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ornithine carbamoyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Head JF]]
[[Category: Head, J F.]]
[[Category: Jin L]]
[[Category: Jin, L.]]
[[Category: Seaton B]]
[[Category: Seaton, B.]]
[[Category: Anabolic]]
[[Category: Carbamyl phosphate]]
[[Category: Transferase]]
[[Category: Urea cycle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:23:27 2008''

Latest revision as of 13:53, 2 August 2023

ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLIORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI

Structural highlights

1akm is a 3 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OTC1_ECOLI Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kuo LC, Miller AW, Lee S, Kozuma C. Site-directed mutagenesis of Escherichia coli ornithine transcarbamoylase: role of arginine-57 in substrate binding and catalysis. Biochemistry. 1988 Nov 29;27(24):8823-32. PMID:3072022
  2. ↑ Legrain C, Stalon V, Glansdorff N. Escherichia coli ornithine carbamolytransferase isoenzymes: evolutionary significance and the isolation of lambdaargF and lambdaargI transducing bacteriophages. J Bacteriol. 1976 Oct;128(1):35-8. PMID:789338

1akm, resolution 2.80Å

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