Caspase: Difference between revisions
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<StructureSection load='1pyo' size='350' side='right' scene='45/458455/Cv/1' caption='CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, [[1pyo]]'> | <StructureSection load='1pyo' size='350' side='right' scene='45/458455/Cv/1' caption='CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, [[1pyo]]'> | ||
'''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br /> | '''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. The CASP recruitment domain (CARD) mediates signaling events that are associated with various human diseases including cancer, neuro-degenerative diseases and immune disorders<ref>PMID:30664151</ref>.<br /> | ||
* '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See:<br /> | * '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See:<br /> | ||
[[Human Caspase-1]]<br /> | [[Human Caspase-1]]<br /> | ||
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[[Student Projects for UMass Chemistry 423 Spring 2012-5]]<br /> | [[Student Projects for UMass Chemistry 423 Spring 2012-5]]<br /> | ||
[[Caspase-3 Regulatory Mechanisms]]<br /> | [[Caspase-3 Regulatory Mechanisms]]<br /> | ||
* '''CASP-4''' binds the lipid moiety of lipopolysaccharide to induce the activation of non-canonical inflammasome<ref>PMID:29339744</ref>.<br/> | |||
* '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See:<br/> | * '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See:<br/> | ||
[[Molecular Playground/Caspase-6 (new)]]<br /> | [[Molecular Playground/Caspase-6 (new)]]<br /> | ||