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| [[Ras Protein and Pancreas Cancer]]<br /> | | [[Ras Protein and Pancreas Cancer]]<br /> |
| [[User:Joseph Lipsick/RAS]]<br /> | | [[User:Joseph Lipsick/RAS]]<br /> |
| | [[H RAS protein (hebrew)]]<br /> |
| [[Chani elisha]]. | | [[Chani elisha]]. |
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| == Structural highlights == | | == Structural highlights == |
| Interactions with the <scene name='37/379455/Cv/6'>nucleotide phosphate moiety in the active site</scene> of GTPase Hras determine its active conformation<ref>PMID:242356730</ref>. Water molecules shown as red spheres. | | Interactions with the <scene name='37/379455/Cv/6'>nucleotide phosphate moiety in the active site</scene> of GTPase Hras determine its active conformation<ref>PMID:242356730</ref>. Water molecules shown as red spheres. <scene name='37/379455/Cv/7'>Mg coordination site</scene>. |
| | ==3D structures of GTPase Hras== |
| | [[GTPase Hras 3D structures]] |
| </StructureSection> | | </StructureSection> |
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| ==3D structures of GTPase Hras==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *HRAS p21 catalytic domain residues 1-166
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| **[[5p21]], [[221p]], [[1ioz]], [[1p2t]], [[3k8y]], [[3l8z]], [[3rry]], [[3tgp]], [[3lbh]], [[4dlr]], [[4dls]], [[4dlt]], [[4dlu]], [[4dlv]], [[4dlw]], [[4dlx]], [[4dly]], [[4dlz]] - hHRAS – human<BR / >
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| **[[1plj]], [[1plk]], [[1pll]] – hHRAS - Laue<BR / >
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| **[[221p]], [[421p]], [[521p]], [[621p]], [[721p]], [[821p]], [[1agp]], [[3i3s]], [[3k9n]], [[3lo5]], [[3k9l]], [[3oiu]], [[3oiv]], [[3oiw]] – hHRAS (mutant)<br />
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| **[[2n42]], [[2n46]] - hHRAS (mutant) – NMR<br />
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| **[[3v4f]] – HRAS - rat
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| *HRAS p21 catalytic domain complex with nucleotides
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| **[[1crp]], [[1crq]], [[1crr]], [[1aa9]] – hHRAS + GDP - NMR<BR / >
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| **[[1q21]], [[4q21]] – hHRAS + GDP<BR / >
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| **[[4l9s]] - hHRAS (mutant) + GDP<br />
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| **[[5vbe]], [[5vbz]] - hHRAS (mutant) + GDP + pyrazole derivative<br />
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| **[[5wdo]] - hHRAS + GMPPNP<br />
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| **[[4l9w]], [[5wdp]], [[5wdq]] - hHRAS (mutant) + GMPPNP<br />
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| **[[6q21]], [[121p]] – hHRAS + GCP<BR / >
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| **[[1qra]] - hHRAS + GTP<BR / >
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| **[[1ctq]], [[4efl]], [[4rsg]], [[5b2z]], [[5b30]], [[5x9s]] - hHRAS + GPPNHP<BR / >
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| **[[1xcm]], [[2cl0]], [[2rga]], [[2rgb]], [[2rgc]], [[2rgd]], [[2rge]], [[2rgg]], [[3kkm]], [[3kkn]], [[4efm]], [[4efn]] - hHRAS (mutant) + GPPNHP<BR / >
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| **[[1gnp]], [[1gnq]] - hHRAS + guanylate derivative<br / >
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| **[[4xvq]], [[4xvr]] - hHRAS (mutant) + guanylate derivative<br />
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| **[[2lcf]] - hHRAS (mutant) + guanylate derivative - NMR<BR / >
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| **[[1p2s]], [[1p2u]], [[1p2v]], [[3rrz]], [[3rs0]], [[3rs2]], [[3rs4]], [[3rs7]], [[3rsl]], [[3rso]] - hHRAS + alcohol + guanylate derivative<br / >
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| **[[3rs3]], [[3rs5]] - hHRAS + small organic molecule + guanylate derivative<br / >
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| **[[3lbh]], [[3lbi]], [[3lbn]] - hHRAS + salt + guanylate derivative<br / >
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| **[[3l8y]] - hHRAS + cyclen + guanylate derivative<br / >
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| **[[1clu]], [[1rvd]], [[1iaq]], [[1gnr]] - hHRAS (mutant) + GTP derivative<br / >
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| **[[1lf0]], [[1zw6]], [[2cl6]], [[2cl7]], [[2clc]], [[2evw]], [[1jah]], [[1jai]]- hHRAS (mutant) + GTP<BR / >
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| **[[1lf5]], [[1xj0]], [[1zvq]], [[2cld]], [[2ce2]], [[2quz]], [[2x1v]], [[2q21]] - hHRAS (mutant) + GDP<BR / >
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| *HRAS p21 catalytic domain complex with protein
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| **[[1wq1]] - hHRAS + p120GAP catalytic domain<BR / >
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| **[[1bkd]], [[1nvw]] - hHRAS + son of sevenless-1<BR / >
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| **[[5wfo]], [[5wfp]], [[5wfq]], [[5wfr]] - hHRAS + son of sevenless-1 homolog<br />
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| **[[1nvu]], [[1nvv]], [[1nvx]], [[1xd2]], [[4nyi]], [[4nyj]], [[4nym]] - hHRAS (mutant) + son of sevenless-1 homolog<BR / >
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| **[[4uru]], [[4urv]], [[4urw]], [[4urx]], [[4ury]], [[4urz]], [[4us0]], [[4us1]], [[4us2]] - hHRAS + son of sevenless-1 + inhibitor<br />
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| **[[1k8r]] - hHRAS + Byr2 RAS-binding domain<BR / >
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| **[[2c5l]] - hHRAS (mutant) + phosphoinositide-specific phospholipase RA2 domain<BR / >
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| **[[2uzi]], [[2vh5]] - hHRAS (mutant) + antibody<BR / >
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| **[[3ddc]] - hHRAS (mutant) + Ras association domain containing family protein RAS-binding domain<BR / >
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| **[[3kud]], [[4g0n]], [[4g3x]] - hHRAS + RAF proto-oncogene Ser/Thr-protein kinase<br />
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| **[[1lfd]] - hHRAS + Ral guanine nucleotide dissociation stimulator RAS-binding domain<br />
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| **[[4k81]] – hHRAS + growth factor receptor-bound protein<br />
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| **[[5e95]] – hHRAS + MB(NS1)<br />
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| **[[6axg]] – hHRAS + Ras guanyl-releasing protein 1<br />
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| **[[5wpl]] – hHRAS + Ras-binding peptide<br />
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| **[[6amb]] – hHRAS + afadin<br />
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| **[[1he8]] – hHRAS (mutant) + P3K<br />
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| *HRAS p21 catalytic domain complex with inhibitor
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| **[[2lwi]] – hHRAS + inhibitor<br />
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| }}
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| ==References== | | ==References== |