6mr9: Difference between revisions

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<StructureSection load='6mr9' size='340' side='right'caption='[[6mr9]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='6mr9' size='340' side='right'caption='[[6mr9]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MR9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MR9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cw7|6cw7]], [[6cxk|6cxk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mr9 OCA], [https://pdbe.org/6mr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mr9 RCSB], [https://www.ebi.ac.uk/pdbsum/6mr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mr9 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mr9 OCA], [http://pdbe.org/6mr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mr9 RCSB], [http://www.ebi.ac.uk/pdbsum/6mr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mr9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Benach, J]]
[[Category: Benach J]]
[[Category: Cao, H]]
[[Category: Cao H]]
[[Category: Frommelt, A]]
[[Category: Frommelt A]]
[[Category: Koss, J]]
[[Category: Koss J]]
[[Category: Morisco, L]]
[[Category: Morisco L]]
[[Category: Rodrigues, J]]
[[Category: Rodrigues J]]
[[Category: Shakhnovich, E]]
[[Category: Shakhnovich E]]
[[Category: Skolnick, J]]
[[Category: Skolnick J]]
[[Category: Complex]]
[[Category: Dhfr]]
[[Category: Oxidoreductase]]
[[Category: Reaction intermediate]]
[[Category: Tetrahydrofolate]]

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