1u9b: Difference between revisions

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<StructureSection load='1u9b' size='340' side='right'caption='[[1u9b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1u9b' size='340' side='right'caption='[[1u9b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1u9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1u9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9B FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9b OCA], [http://pdbe.org/1u9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9b RCSB], [http://www.ebi.ac.uk/pdbsum/1u9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9b OCA], [https://pdbe.org/1u9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9b RCSB], [https://www.ebi.ac.uk/pdbsum/1u9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE]] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref>
[https://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Bernards R]]
[[Category: Bernards, R]]
[[Category: Hateboer G]]
[[Category: Hateboer, G]]
[[Category: Perrakis A]]
[[Category: Perrakis, A]]
[[Category: Sixma TK]]
[[Category: Sixma, T K]]
[[Category: Tong H]]
[[Category: Tong, H]]
[[Category: Cell cycle control]]
[[Category: Ligase]]
[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Ubiquitin-directed proteolysis]]

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