6ljh: Difference between revisions

Latest revision as of 14:01, 22 November 2023

Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+

Structural highlights

6ljh is a 1 chain structure with sequence from Artemisia annua. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADH1_ARTAN Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:23575629, PubMed:27488942). Catalyzes the conversion of artemisinic alcohol into artemisinic aldehyde (PubMed:23575629).^[1] ^[2]

References

↑ Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature. 2013 Apr 25;496(7446):528-32. PMID:23575629 doi:10.1038/nature12051
↑ Tu Y. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture). Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10210-26. PMID:27488942 doi:10.1002/anie.201601967

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OCA

[1] Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature. 2013 Apr 25;496(7446):528-32. PMID:23575629 doi:10.1038/nature12051

[2] Tu Y. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture). Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10210-26. PMID:27488942 doi:10.1002/anie.201601967

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ljh is ON HOLD
+==Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+==
+<StructureSection load='6ljh' size='340' side='right'caption='[[6ljh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_annua Artemisia annua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LJH FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ljh OCA], [https://pdbe.org/6ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ljh RCSB], [https://www.ebi.ac.uk/pdbsum/6ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ljh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ADH1_ARTAN ADH1_ARTAN] Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:23575629, PubMed:27488942). Catalyzes the conversion of artemisinic alcohol into artemisinic aldehyde (PubMed:23575629).<ref>PMID:23575629</ref> <ref>PMID:27488942</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Artemisia annua]]
+[[Category: Large Structures]]
+[[Category: Fan S]]
+[[Category: Feng X]]
+[[Category: Jin Y]]
+[[Category: Li M]]
+[[Category: Lv G]]
+[[Category: Wu G]]
+[[Category: Yang Z]]
+[[Category: Zou S]]

6ljh: Difference between revisions

Latest revision as of 14:01, 22 November 2023

Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+

Structural highlights

Function

References

Contents

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6ljh: Difference between revisions

Latest revision as of 14:01, 22 November 2023

Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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