Mitogen-activated protein kinase: Difference between revisions

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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 == Function ==
 [[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more.  MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>.  <br />
+See also [[Mitogen-activated protein kinase cascade]].
 * '''MAPK1''' or '''ERK2''' and '''MAPK3''' are activated in response to growth factors.  For '''MAPK1''' representations see [[Michael Roberts/BIOL115/ERK2]].<br />
 *  '''MAPK6''' is activated by phorbol esters.<br />
 * '''MAPK7''' is activated by stress stimuli.<br />
 *  '''MAPK8 (called also c-Jun N-terminal kinase 1 or JNK1), MAPK9, MAPK10''' (called also c-Jun N-terminal kinase 3 or JNK3), '''MAPK11, MAPK12, MAPK13, MAPK14''' are stress-activated.<br />
-* '''MAPK11''' (also called '''p38-β MAPK'''),  '''MAPK12''' (also called '''p38-γ MAPK'''),  '''MAPK13''' (also called '''p38-δ MAPK'''),  '''MAPK14''' (also called '''p38-α MAPK''') belongs to the class called [[UMass Chem 423 Student Projects 2011-2#p38 kinase|UMass Chem 423 Student Projects 2011-2: p38 MAPK]]|.
+* '''MAPK11''' (also called '''p38-β MAPK'''),  '''MAPK12''' (also called '''p38-γ MAPK'''),  '''MAPK13''' (also called '''p38-δ MAPK'''),  '''MAPK14''' (also called '''p38-α MAPK''') belongs to the class called [[UMass Chem 423 Student Projects 2011-2#p38 kinase|p38 MAPK (UMass Chem 423 Student Projects 2011-2)]].
 == Relevance ==