6cvk: Difference between revisions

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 <StructureSection load='6cvk' size='340' side='right'caption='[[6cvk]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6cvk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Hbv Hbv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CVK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6cvk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CVK FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C, preC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 HBV])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cvk OCA], [http://pdbe.org/6cvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cvk RCSB], [http://www.ebi.ac.uk/pdbsum/6cvk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cvk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cvk OCA], [https://pdbe.org/6cvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cvk RCSB], [https://www.ebi.ac.uk/pdbsum/6cvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cvk ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/L7R8Z1_HBV L7R8Z1_HBV] May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.[RuleBase:RU361253]  Self assembles to form an icosahedral capsid. Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsids are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stuck in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.[HAMAP-Rule:MF_04076]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 6cvk" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: European rabbit]]
+[[Category: Hepatitis B virus]]
-[[Category: Hbv]]
 [[Category: Large Structures]]
-[[Category: Eren, E]]
+[[Category: Oryctolagus cuniculus]]
-[[Category: Steven, A C]]
+[[Category: Eren E]]
-[[Category: Wingfield, P T]]
+[[Category: Steven AC]]
-[[Category: E-antigen]]
+[[Category: Wingfield PT]]
-[[Category: Hepatitis b]]
-[[Category: Single chain variable fragment]]
-[[Category: Viral protein]]
-[[Category: Viral protein-immune system complex]]