6tky: Difference between revisions
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==Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42== | |||
<StructureSection load='6tky' size='340' side='right'caption='[[6tky]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6tky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TKY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tky OCA], [https://pdbe.org/6tky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tky RCSB], [https://www.ebi.ac.uk/pdbsum/6tky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tky ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] | |||
==See Also== | |||
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]] | |||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: Barford | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Fan | [[Category: Large Structures]] | ||
[[Category: | [[Category: Barford D]] | ||
[[Category: Cronin N]] | |||
[[Category: Fan D]] | |||
[[Category: Yang J]] | |||
Latest revision as of 16:04, 24 January 2024
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Structural highlights
FunctionDOC10_HUMAN Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] See Also |
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