6j2g: Difference between revisions

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<StructureSection load='6j2g' size='340' side='right'caption='[[6j2g]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='6j2g' size='340' side='right'caption='[[6j2g]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6j2g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_flying_fox Black flying fox] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J2G FirstGlance]. <br>
<table><tr><td colspan='2'>[[6j2g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pteropus_alecto Pteropus alecto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J2G FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ptal-N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9402 Black flying fox]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j2g OCA], [http://pdbe.org/6j2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j2g RCSB], [http://www.ebi.ac.uk/pdbsum/6j2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j2g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j2g OCA], [https://pdbe.org/6j2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j2g RCSB], [https://www.ebi.ac.uk/pdbsum/6j2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j2g ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
[https://www.uniprot.org/uniprot/A0A125R585_PTEAL A0A125R585_PTEAL]  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<div class="pdbe-citations 6j2g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6j2g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Black flying fox]]
[[Category: Ebola virus sp]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chai, Y]]
[[Category: Pteropus alecto]]
[[Category: Cheng, H]]
[[Category: Chai Y]]
[[Category: Gao, G F]]
[[Category: Cheng H]]
[[Category: Liu, K F]]
[[Category: Gao GF]]
[[Category: Liu, W J]]
[[Category: Liu KF]]
[[Category: Lu, D]]
[[Category: Liu WJ]]
[[Category: Lu, Q]]
[[Category: Lu D]]
[[Category: Qi, J X]]
[[Category: Lu Q]]
[[Category: Yue, C]]
[[Category: Qi JX]]
[[Category: Immune system]]
[[Category: Yue C]]

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