5uxh: Difference between revisions

<table><tr><td colspan='2'>[[5uxh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UXH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GFB:GUANOSINE-5-DIPHOSPHATE-BETA-L-FUCOPYRANOSE'>GFB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxh OCA], [https://pdbe.org/5uxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uxh RCSB], [https://www.ebi.ac.uk/pdbsum/5uxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxh ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/OFUT1_HUMAN OFUT1_HUMAN] Dowling-Degos disease. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/OFUT1_HUMAN OFUT1_HUMAN] Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).<ref>PMID:11524432</ref> <ref>PMID:8358148</ref>  

[[Category: Homo sapiens]]

[[Category: Blacklow SC]]

[[Category: McMillan B]]

[[Category: Xu X]]