5uno: Difference between revisions

<table><tr><td colspan='2'>[[5uno]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UNO FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.603&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uno OCA], [https://pdbe.org/5uno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uno RCSB], [https://www.ebi.ac.uk/pdbsum/5uno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uno ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HIP1_MYCTU HIP1_MYCTU] Serine protease that promotes tuberculosis (TB) pathogenesis by promoting the processing and the extracellular release of the M.tuberculosis (Mtb) heat-shock protein GroEL2 (PubMed:18172199, PubMed:24830429, PubMed:28346784). Hip1-dependent cleavage of multimeric GroEL2 results in release of cleaved monomeric GroEL2 into the extracellular milieu. Conversion of multimeric GroEL2 into monomeric GroEL2 is likely to be a mechanism for regulating GroEL2 functions during Mtb pathogenesis (PubMed:24830429). In vitro, exhibits proteolytic activity against synthetic peptides and the general protease substrate azocasein, and exhibits esterase activity against the ester substrate p-nitrophenylbutyrate (PubMed:24830429, PubMed:28346784).<ref>PMID:18172199</ref> <ref>PMID:24830429</ref> <ref>PMID:28346784</ref>  Key immunomodulatory virulence factor, which promotes survival in host macrophages and modulates host immune responses (PubMed:18172199, PubMed:21947769, PubMed:24659689). Impacts host innate immune responses by preventing robust macrophage activation (PubMed:18172199, PubMed:21947769). Dampens macrophage pro-inflammatory responses by limiting toll-like receptor 2 (TLR2) activation. It also dampens TLR2-independent activation of the inflammasome and limits secretion of interleukin-18 (IL-18). May act by masking cell surface interactions between TLR2 agonists on Mtb and TLR2 on macrophages (PubMed:21947769). In addition, impacts host adaptive immune responses. It prevents robust maturation of infected dendritic cells (DCs), limits the secretion of key pro-inflammatory cytokines such as IL-12, impairs Ag presentation, and modulates the nature of Ag-specific T-cell responses (PubMed:24659689).<ref>PMID:18172199</ref> <ref>PMID:21947769</ref> <ref>PMID:24659689</ref>  

[[Category: Mycobacterium tuberculosis H37Rv]]

[[Category: Daab A]]

[[Category: Dunn BM]]

[[Category: Goldfarb N]]

[[Category: Liu D]]

[[Category: Milne AC]]

[[Category: Naffin-Olivos JL]]

[[Category: Petsko GA]]

[[Category: Rengarajan J]]

[[Category: Ringe D]]

[[Category: White A]]