6tkk: Difference between revisions
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New page: '''Unreleased structure''' The entry 6tkk is ON HOLD Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S. Description: Neuropilin 1-b1 domain in a complex with the C-t... |
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The | ==Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide== | ||
<StructureSection load='6tkk' size='340' side='right'caption='[[6tkk]], [[Resolution|resolution]] 1.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6tkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TKK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.06Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tkk OCA], [https://pdbe.org/6tkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tkk RCSB], [https://www.ebi.ac.uk/pdbsum/6tkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tkk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. | |||
==See Also== | |||
*[[Neuropilin|Neuropilin]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Djordjevic S]] | ||
[[Category: | [[Category: Eldrid C]] | ||
[[Category: | [[Category: Fotinou C]] | ||
[[Category: Yelland T]] | |||
[[Category: Yu L]] | |||
Latest revision as of 16:04, 24 January 2024
Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptideNeuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
Structural highlights
FunctionNRP1_HUMAN The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. See Also |
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