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| | ==ORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTURE== |
| The line below this paragraph, containing "STRUCTURE_197d", creates the "Structure Box" on the page.
| | <StructureSection load='197d' size='340' side='right'caption='[[197d]], [[Resolution|resolution]] 2.19Å' scene=''> |
| You may change the PDB parameter (which sets the PDB file loaded into the applet)
| | == Structural highlights == |
| or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| | <table><tr><td colspan='2'>[[197d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=197D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=197D FirstGlance]. <br> |
| or leave the SCENE parameter empty for the default display.
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> |
| -->
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=197d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=197d OCA], [https://pdbe.org/197d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=197d RCSB], [https://www.ebi.ac.uk/pdbsum/197d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=197d ProSAT]</span></td></tr> |
| {{STRUCTURE_197d| PDB=197d | SCENE= }}
| | </table> |
| | | __TOC__ |
| '''ORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTURE'''
| | </StructureSection> |
| | | [[Category: Large Structures]] |
| | | [[Category: Courseille C]] |
| ==Overview== | | [[Category: Dautant A]] |
| The X-ray crystal structure of the double-helical A-DNA octanucleotide d(GTACGTAC) has been solved by molecular replacement and refined to a resolution of 0.219 nm. The final R-factor is equal to 16.1% for 1516 observed reflections with F > 4 sigma(F). The sequence crystallizes as an A-DNA-type double helix in the orthorhombic space group P2(1)2(1)2, with one duplex molecule solvated by 66 water molecules in the asymmetric unit. Cell parameters are a = 3.860 nm, b = 5.082 nm, c = 2.174 nm. It is the first time that such a crystal form has been observed. This orthorhombic structure has been compared with the tetragonal structure of the same oligonucleotide. It adopts a bent structure with an unusual packing between symmetry-related molecules.
| | [[Category: Langlois D'Estaintot B]] |
| | | [[Category: Precigoux G]] |
| ==About this Structure==
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| Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=197D OCA]. | |
| | |
| ==Reference== | |
| Orthorhombic crystal structure of the A-DNA octamer d(GTACGTAC). Comparison with the tetragonal structure., Langlois d'Estaintot B, Dautant A, Courseille C, Precigoux G, Eur J Biochem. 1993 Apr 15;213(2):673-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8477741 8477741]
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| [[Category: Courseille, C.]] | |
| [[Category: Dautant, A.]] | |
| [[Category: Estaintot, B Langlois D.]] | |
| [[Category: Precigoux, G.]] | |
| [[Category: A-dna]] | |
| [[Category: Double helix]] | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:35:43 2008''
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