6ti1: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ti1 is ON HOLD
+==SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with PLP/L-Threonine/Lys230 gem diamine complex==
+<StructureSection load='6ti1' size='340' side='right'caption='[[6ti1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ti1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TI1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BO:N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-THREONINE'>2BO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ti1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ti1 OCA], [https://pdbe.org/6ti1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ti1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ti1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ti1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
-Authors: Petrillo, G., Hernandez, K., Bujons, J., Clapes, P., Uson, I.
+==See Also==
+*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
-Description: SHMTSth Tyr55Thr in complex with D-Ser both as external aldimine and as non-covalent complex
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Petrillo, G]]
+[[Category: Large Structures]]
-[[Category: Bujons, J]]
+[[Category: Streptococcus thermophilus]]
-[[Category: Uson, I]]
+[[Category: Bujons J]]
-[[Category: Hernandez, K]]
+[[Category: Clapes P]]
-[[Category: Clapes, P]]
+[[Category: Hernandez K]]
+[[Category: Petrillo G]]
+[[Category: Uson I]]